Imaging of Neuro-Inflammation

Vasogenic edema is associated with BBB dysfunction, which allows an increase in the passage of plasma proteins and water into the extracellular compartment [3, 5]. This is the main type of edema associated with inflammation and will be the main focus of this thesis. In hydrocephalus, a rise in intraventricular pressure causes the cerebro-spinal fluid (CSF) to migrate through the ependyma into the periventricular white matter. The resulting increase of fluid into the periventricular white matter is quite similar to vasogenic edema but differs because it has the same composition as CSF without serum proteins. It is known as hydrocephalic edema [3, 5].